Jianing Fu, PhD

  • Assistant Professor of Medical Sciences (in Medicine)
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Overview

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine)

Languages

  • Chinese

Gender

  • Female

Credentials & Experience

Education & Training

  • BS, 2008 Pharmaceutical Sciences, Peking University
  • MS, 2010 Chemical Biology, Peking University
  • Graduate Certificate, 2013 Clinical Investigation, University of South Florida
  • PhD, 2015 Cancer Biology (and Immunology), University of South Florida

Honors & Awards

  • 2022 USERN Prize Laureate in Biological Sciences, USERN (Universal Scientific Education and Research Network)
  • 2020/2021/2022 Nelson Family Transplant Innovation Awards, CUMC
  • 2022 Community of Transplant Scientists (COTS) registration bursary
  • 2020 The Federation of Clinical Immunology Societies (FOCIS) Travel Award
  • 2020 FCE (FOCIS Center of Excellence) Travel Award
  • 2020 Top scored abstract, The Transplantation Society (TTS)
  • 2019 Discovery Award, Department of Defense
  • 2019 Transplant Forum Scholar Award, CUMC
  • 2019 Medicine Grand Rounds, Fellow Research Presentation Award, CUMC
  • 2018 Outstanding Oral Presentation Award, CCTI Research Day
  • 2017/2018 International Transplantation Science Mentee-Mentor Awards, TTS
  • 2017 Best Abstract, The Intestinal Rehabilitation & Transplant Association (IRTA)
  • 2016 Young Investigator Scientific Award, TTS
  • 2015 Outstanding Thesis & Dissertation Award, University of South Florida (USF)
  • 2012/2014 Abstract Achievement Awards, American Society of Hematology
  • 2012/2013 Cancer Biology Travel Awards, USF
  • 2012 Cancer Biology Student Organization Community Service Award, USF
  • 2008 Excellent Volunteer in Beijing Olympic Games (Anti-doping Agency)
  • 2006/2007/2008 Scholarships for Excellent Medical Students, Peking University
  • 2023 The Federation of Clinical Immunology Societies (FOCIS) Travel Award

Research

Dr. Jianing Fu is an Assistant Professor in the Department of Medicine and a principal investigator at the Columbia Center for Translational Immunology (CCTI). Dr. Fu obtained her BS degree in Pharmaceutical Sciences and MS degree in Chemical Biology from Peking University (China) and received her PhD in Cancer Biology and Immunology from University of South Florida and H. Lee Moffitt Cancer Center. She did a Curricular Practical Training at Medical University of South Carolina to complete her doctoral education. Dr. Fu joined Columbia University in May 2015 to start her postdoctoral training and later took the lead on several projects related to human organ transplantation under the roles of Associate Research Scientist and Instructor.

At Columbia, Dr. Fu’s laboratory is conducting translational research on decoding the graft-versus-host (GvH) and host-versus-graft (HvG) alloreactivity after human intestinal transplantation and lung transplantation. Her research also extends in investigating the phenotype and function of gut and lung hematopoietic stem cells and progenitors, with the ultimate goal of eliminating graft rejection by inducing long persistent blood mixed chimerism. Dr. Fu has established long term multidisciplinary collaboration with transplant surgeons, adult and pediatric physicians, pathologists, bioinformatic scientists and translational immunologists to perform cutting edge human transplantation studies.


Grants

• 2022-2024 Nelson Faculty Development Award, CUMC. PI: Fu.
Functional profile, migration pattern and microenvironment of human hematopoietic stem and progenitor cells residing in ectopic organ sites under physiological and inflammatory conditions

• 2021-2024 R21, NIH/NIAID, AI166069-01. PI: Fu.
Immune profiling of gamma delta T cells after human intestinal transplantation. 

• 2021-2023 Nelson Faculty Development Award, CUMC. PI: Fu.
Chimerism and immune repertoire of human gamma delta T cells after human lung transplantation.

• 2020-2022 Discovery Award, DoD, W81XWH-20-1-0159. PI: Fu.
Single Cell Immune Profiling of Alloreactive T cells Locally and Systemically in Patients Receiving Intestinal Transplantation.

• 2020-2021 Nelson Faculty Development Award, CUMC. PI: Fu.
Phenotypic and clonal tracking of human gamma delta T cells after human intestinal transplantation

 


Selected Publications

  • Fu J*, Wang Z, Martinez M, Jiao W, Frangaj K, Jones R, Guo X, Zhang Y, Kuo W-I, Ko H, Iuga A, Obradovic A, Bay Muntnich C, Rogers K, Zuber J, Ma W, Miron M, Farber D, Kato T, Shen Y, Sykes M*. Heterogeneity and Plasticity of Alloreactive T Cells in Human Intestinal Allografts: New Insights into Tissue Residency and Immune Tolerance after Transplantation. Journal of Experimental Medicine. 2024. 221 (1): e20230930. (*Co-corresponding author)
  • Long K, Fu J*. Chimerism and phenotypic analysis of intraepithelial and lamina propria T lymphocytes isolated from fresh human ileal biopsies after intestinal transplantation. STAR Protocols. 2023, 4 (2), 102192. (*Corresponding author)
  • Wu Y, Zuber J and Fu J*. Editorial: Immunogenomics of Solid Organ and Hematopoietic Stem Cell Transplantation. Frontiers in Immunology. 2022, 13:878314. (*Corresponding author)
  • Fu J, Sykes M. Emerging Concepts of Tissue-Resident Memory T cells in Transplantation. Transplantation. 2022 Jun 1;106(6):1132-1142.
  • Obradovic A, Shen Y, Sykes M, Fu J*. Integrated Analysis Toolset for Defining and Tracking Alloreactive T-cell Clones After Human Solid Organ and Hematopoietic Stem Cell Transplantation. Software Impacts. 2021 (10) 100142 (*Corresponding author)  
  • Fu J#, Khosravi-Maharlooei M, Sykes M. High throughput human T cell receptor sequencing: a new window into repertoire establishment and alloreactivity. Frontiers in Immunology. 2021, 12:777756. #Co-first author.
  • Fu J, Zuber J, Shonts B, Obradovic A, Wang Z, Frangaj K, Meng W, Rosenfeld A, Waffarn E, Liou P, Lau S-p, Savage T, Yang S, Rogers K, Danzl Nichole, Ravella S, Satwani P, Iuga A, Ho S-h, Griesemer A, Shen Y, Luning-Prak E, Martinez M, Kato T, Sykes M. Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation. Journal of Clinical Investigation. 2021 Apr 15;131(8):e141698.
  • Fu J, Zuber J, Martinez M, Shonts B, Obradovic A, Wang H, Lau S-p, Xia A, Waffarn E, Frangaj K, Savage T, Simpson T, Yang S, Guo X, Miron M, Senda T, Rogers K, Rahman A, Ho S-h, Shen Y, Griesemer A, Farber D, Kato T, Sykes M. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that are Maintained by a Circulating Pool. Cell Stem Cell. 2019 Feb 7;24(2):227-239.e8. (Commentary: “We Could Use More Tolerance: Role of Intestinal-Allograft- Derived Human Stem Cells”.)
  • Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, and Yu X-Z. T-bet promotes acute graft-versus-host disease by regulating recipient hematopoietic cells in mice. J Immunol. 2016 Apr 1; 196 (7): 3168-3179. Cover Article.
  • Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald D, Anasetti C, and Yu X-Z. T-bet is critical for the development of acute graft-versus-host disease through controlling T-cell differentiation and function. J Immunol. 2015 Jan 1;194(1):388-97.
  • Fu J, Heinrichs J, Yu X. Helper T-cell Differentiation in Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Arch Immunol Ther Exp. 2014 Aug; 62(4): 277-301