Krzysztof Kiryluk, MD
Overview
Dr. Krzysztof Kiryluk is a Professor of Medicine with tenure at Columbia University. He received his medical degree at the Columbia College of Physicians & Surgeons, completed his residency in Internal Medicine at the Massachusetts General Hospital, Harvard University, and Nephrology fellowship training at the NewYork-Presbyterian Hospital, Columbia University. Dr. Kiryluk specializes in the treatment of chronic kidney disease, glomerulonephritis, and inherited kidney disorders.
Dr. Kiryluk is a physician-scientist, and serves as the Interim Chief of Nephrology at Columbia University. His research aims to define genetic factors contributing to the risk of kidney disease. Dr. Kiryluk leads several large collaborative national and international genetic studies of glomerular disorders, such as IgA nephropathy, IgA vasculitis, and membranous nephropathy. Some of Dr. Kiryluk’s interests fall at the interface of research and clinical care. For example, he is leading precision medicine studies involving integrated genomic risk assessment with return of genetic results to patients and clinicians. He is also working on the development of new informatics methods to harness the power of “big data” (clinical and molecular) to enhance genetic discovery and improve clinical care of kidney patients.
Dr. Kiryluk has authored multiple publications and is a recipient of several prestigious awards, including the Donald W. Seldin Young Investigator Award from the American Society of Nephrology. He is an active member of the American Society of Clinical Investigation, American Society of Human Genetics, American Society of Nephrology, and International Society of Nephrology. He also serves as an associate editor of Kidney International. His research has been supported by federal grants from the National Institute of Diabetes and Digestive and Kidney Disease, National Human Genome Research Institute, National Center for Advancing Translational Sciences, National Library of Medicine, as well as private foundations.
Areas of Expertise / Conditions Treated
- Clinical Molecular Genetics
- Genetic Disorder
- Glomerular Diseases and Nephrotic Syndrome
- Glomerulonephritis
- Hypertension
- Kidney Disease
Academic Appointments
- Professor of Medicine
Administrative Titles
- Interim Division Chief, Division of Nephrology
- Associate Director, Columbia CTSA Precision Medicine Resource
Hospital Affiliations
- NewYork-Presbyterian / Columbia University Irving Medical Center
Gender
- Male
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Location(s)
Insurance Accepted
Affinity Health Plan
Amida Care
Cigna
Emblem/GHI
Emblem/HIP
Empire Blue Cross/Blue Shield
Empire Blue Cross Blue Shield HealthPlus
Fidelis Care
Healthfirst
Local 1199
MagnaCare (National)
Medicare
Multiplan
MVP Health Care
RiverSpring
UnitedHealthcare
WellCare
World Trade Center Health Plan
Credentials & Experience
Education & Training
- MD, Columbia University College of Physicians and Surgeons
- MPH, Biostatistics, Columbia University Mailman School of Public Health
- Residency: Massachusetts General Hospital
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
Committees, Societies, Councils
- Associate Editor, Kidney International
- American Society of Clinical Investigation
- American Society of Human Genetics
- International Society of Nephrology
- American Society of Nephrology
Board Certifications
- Nephrology
- Internal Medicine
Honors & Awards
- 2021: Donald W. Seldin Young Investigator Award, American Society of Nephrology and American Heart Association
- 2020: The American Society of Clinical Investigation (ASCI) elected member
- 2019: The Harold and Golden Lamport Award for Excellence in Clinical Science Research, Columbia University
- 2017: Ewig Clinical Scholar Award, Columbia University
- 2017: Innovations in Kidney Education Award, American Society of Nephrology
- 2015: Herbert Irving Scholar, College of Physicians & Surgeons, Columbia University
- 2014: Carl W. Gottschalk Research Scholar, American Society of Nephrology
- 2011: Marc Anthony Zambetti Assistant Professorship, College of Physicians & Surgeons, Columbia University
- 2009: Young Investigator Award, American Society of Hypertension
- 2008: Daland Fellow in Clinical Investigation, American Philosophical Society
- 2006: Patient Oriented Research Scholar, Irving Institute-Mailman School of Public Health
- 2002: Alpha Omega Alpha
Research
The Kiryluk Laboratory aims to discover genes and genetic mechanisms involved in the pathogenesis of common forms of kidney disease. We focus on the genetic studies of glomerular disorders, including IgA nephropathy, IgA vasculitis, and membranous nephropathy. We are also interested in the effects of ancestry on the risk of kidney disease among worldwide populations. We use genetic and genomic approaches and novel statistical and computational methods to characterize the molecular and clinical consequences of inherited genetic variation. Through our work, we aim to improve the existing diagnostic tools, personalize disease treatments, and lay the basis for development of novel effective therapies.
Research Interests
- Complex Traits
- Electronic Health Records (EHR/EMR)
- Genetic Studies
- Genomics
- Kidney Disease
- Polygenic Risk Score
- Precision Medicine
Grants
- RC2-DK116690 NIDDK
“Genomics of Glomerular Disease” - R01-DK105124 NIDDK
“Genetics of IgA nephropathy by network-based association studies” - R01-DK136765 NIDDK
“Non-APOL1 genetic factors and kidney transplant outcomes” - R01-LM013061 NLM
“Big Data Methods for Comprehensive Similarity-based Risk Prediction” - UH3-DK114926 NIDDK
“Kidney Precision Medicine Project (KPMP)” - U01-HG008680 NHGRI
“EHR Genomic Risk Assessment and Management for Diverse Populations” - U01-AI152960 NIAID
“MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies”
Selected Publications
- Khan A ... Kiryluk K. Polygenic risk affects the penetrance of monogenic kidney disease. Nature Communications 2023;14(1):8318.
- Kiryluk K et al. Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nature Genetics 2023 Jul;55(7):1091-1105.
- Khan A ... Kiryluk K. Genome-wide polygenic score to predict CKD across ancestries. Nature Medicine 2022. 28(7):1412-1420.
- Liu L ... Kiryluk K. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. Nature Communications 2022; 13(1):6859.
- Shang N ... Kiryluk K. Medical Records-based Kidney Disease Phenotype for Clinical Care and “Big Data” Observational and Genetic Studies. NPJ Digital Medicine 2021; 4(1):70.
- Xie J ... Kiryluk K. Genetic Architecture of Membranous Nephropathy and Its Diagnostic Implications. Nature Communications 2020;11(1):1600.
- Steers NJ ... Kiryluk K. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. New England Journal of Medicine. 2019;380(20):1918-1928.
- Kiryluk K et al. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway PLoS Genetics, 2017; 10;13(2):e1006609.
- Kiryluk K et al. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nature Genetics 2014; 46(11):1187-96.
For a complete list of publications, please visit PubMed.gov(link is external and opens in a new window)