Krzysztof Kiryluk, MD

Specialties:
Nephrology, Internal Medicine
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Overview

Dr. Krzysztof Kiryluk is a physician-scientist in the Division of Nephrology, Department of Medicine at Columbia University. He received his medical degree at the Columbia College of Physicians & Surgeons, completed his residency in Internal Medicine at the Massachusetts General Hospital, Harvard University, and Nephrology fellowship at the NewYork-Presbyterian Hospital, Columbia University. Dr. Kiryluk specializes in the treatment of chronic kidney disease, glomerulonephritis, and inherited kidney disorders.

Dr. Kiryluk holds the Herbert Irving Assistant Professorship at Columbia University. His research aims to define genetic factors contributing to the risk of kidney disease. Dr. Kiryluk leads several large collaborative national and international genetic studies of glomerular disorders. He has authored multiple publications and is an active member of the American Society of Human Genetics, American Society of Nephrology, and International Society of Nephrology. He is a recipient of several prestigious fellowship awards, including the Carl W. Gottschalk Research Scholar Award from the American Society of Nephrology and the Daland Fellowship from the American Philosphical Society. Dr. Kiryluk's research has been supported by federal grants from the National Institute of Diabetes and Digestive and Kidney Disease, National Center for Advancing Translational Sciences, and private foundations.

Areas of Expertise / Conditions Treated

  • Clinical Molecular Genetics
  • Genetic Disorder
  • Glomerular Diseases and Nephrotic Syndrome
  • Glomerulonephritis
  • Hypertension
  • Kidney Disease

Academic Appointments

  • Assistant Professor of Medicine at CUMC

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Male

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Location(s)

1150 St. Nicholas Avenue
Room #413
New York, NY 10032

Insurance Accepted

Aetna

  • Aetna Signature Administrators
  • EPO
  • HMO
  • Medicare Managed Care
  • NYP Employee Plan
  • NY Signature
  • POS
  • PPO
  • Student Health

Affinity Health Plan

  • Essential Plan
  • Medicaid Managed Care

AgeWell

  • Medicare Managed Care
  • Special Needs

Amida Care

  • Special Needs

Cigna

  • EPO
  • Great West (National)
  • HMO
  • POS
  • PPO

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross/Blue Shield

  • EPO
  • HMO
  • Medicare Managed Care
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare

Medicare

  • Railroad
  • Traditional Medicare

Multiplan

  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty

RiverSpring

  • Special Needs

UnitedHealthcare

  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • Medicare Managed Care
  • SelectHealth
  • Special Needs

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

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Credentials & Experience

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Residency: Massachusetts General Hospital
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

  • Nephrology
  • Internal Medicine

Honors & Awards

Alpha Omega Alpha
2000 The ASCP Award for Academic Excellence & Achievement
2002 Scholarly Resources and Pathology Creative Collaboration Award
2002 Dr. Meierhof Prize for Outstanding Achievement in Pathology
2006 Irving Institute-Mailman School of Public Health POR Scholarship
2008 Daland Fellow in Clinical Investigation, American Philosophical Society
2009 Young Investigator Award, American Society of Hypertension
2011 Zambetti Fellowship, Columbia University
2014 Carl W. Gottschalk Research Scholar, American Society of Nephrology
2015 Herbert Irving Assistant Professorship, Columbia University

Research

Our studies aim at discovery of genes and pathways involved in the pathogenesis of kidney disease. We focus on the genetic architecture of glomerular disorders, including IgA nephropathy, membranous nephropathy, C3 glomerulopathy, and focal segmental glomerulosclerosis. We are also interested in human population genetics and the effects of ancestral backgroud on the risk of kidney disease among diverse populations worldwide. Our lab works on the mapping of common genetic variation predisposing to kidney injury in general population, as well as the identification of causal mutations in rare forms of familial kidney disorders. We use state-of-the-art genetic approaches and novel statistical and computational methods, including genome-wide association mapping, analysis of human copy number variation, linkage mapping, genome sequencing, construction of transcriptional gene regulatory networks, and the generation of animal models to study the consequences of pathogenic mutations. Through our work, we aim to improve the existing diagnostic tools, personalize and refine disease treatments, and lay the basis for development of novel effective therapies.

Research Interests

  • C3 glomerulopathy and genetic regulation of the complement system
  • Genetics of IgA nephropathy and other glomerular disorders
  • Genetics of kidney and urinary tract malformations
  • Personalized genomics of solid organ transplantation

Grants

  • GWAS-based pathogenesis model of IgA nephropathy, Carl W. Gottschalk Research Scholar Grant, ASN Foundation for Kidney Research.
  • Donor-recipient genomic incompatibilities in solid organ transplantation, New York Presbyterian Hospital Translational Grant Program.
  • Kidney Dashboard: An Integrated Support Tool for Clinical Care and Research of Kidney Disorders, CTSA/DBMI Pilot Award.

Selected Publications

  • Kiryluk K, Moldoveanu Z, Sanders JT, Eison TM, Suzuki H, Julian BA, Novak J, Gharavi AG, Wyatt RJ. (2011) Aberrant glycosylation of IgA1 is inherited in pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis. Kidney International 80:79-87
  • Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, Eitner F, Snyder HJ, Choi M, Hou P, Scolari F, Izzi C, Gigante M, Gesualdo L, Savoldi S, Amoroso A, Cusi D, Zamboli P, Julian BA, Novak J, Wyatt RJ, Mucha K, Perola M, Kristiansson K, et al. (2012) Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genetics 8(6):e1002765
  • Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, et al. (2011) Genome wide association study identifies susceptibility loci for IgA nephropathy. Nature Genetics 43:321-327
  • Papeta N, Kiryluk K, Patel A, Sterken R, Kacak N, Snyder HJ, Imus PH, Mhatre AN, Lawani AK, Julian BA, Wyatt RJ, Novak J, Wyatt CM, Ross MJ, Winston JA, Klotman ME, Cohen DJ, Appel GB, D'Agati VD, Klotman PE, Gharavi AG. (2011) APOL1 genetic variants significantly increase susceptibility to focal segmental glomerulosclerosis and HIV-1 associated nephropathy but not IgA nephropathy in African Americans. JASN 22 (11):1991-6
  • Sanna-Cherchi S, Kiryluk K, Burgess KE, Bodria M, Sampson MG, Hadley D, Nees SN, Verbitsky M, Perry BJ, Sterken R, Lozanovski VJ, Materna-Kiryluk A, Barlassina C, Kini A, Corbani V, Carrea A, Somenzi D, Murtas C, et al. (2012) Copy-number Disorders Are a Common Cause of Congenital Kidney Malformations. AJHG 91(6):987-97
  • Kiryluk K, Novak J, Gharavi AG. (2013) Genetics of IgA Nephropathy: Insight from the Genetic Studies. Ann Rev Medicine 64:339-56
  • Sanna-Cherchi S, Sampogna RV, Papeta N, Burgess KE, Nees SN, Perry BJ, Choi M, Bodria M, Liu Y, Weng PL, Lozanovski VJ, Verbitsky M, Lugani F, Sterken R, Paragas N, Caridi G, Kiryluk K, Al-Awqati Q, D'Agati VD, Drummond IA, Tasic V, Lifton RP, et al. (2013) Mutations in DSTYK and dominant urinary tract malformations. NEJM 369(7):621-9
  • Materna-Kiryluk A, Kiryluk K, Burgess KE, Bieleninik A, Sanna-Cherchi S, Gharavi AG, Latos-Bielenska A. (2014) The emerging role of genomics in the diagnosis and workup of congenital urinary tract defects: a novel deletion syndrome on chromosome 3q13.31-22.1. Pediatr Nephrol. 29(2):257-67
  • Kiryluk K and Novak J. (2014) The Genetics and immunobiology of IgA nephropathy. JCI 124(6):2325-32
  • Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, Fasel D, Lata S, Prakash S, Shapiro S, Fischman C, Snyder HJ, Appel G, Izzi C, Viola BF, Dallera N, Del Vecchio L, Barlassina C, Salvi E, Bertinetto FE, Amoroso A, Savoldi S, Rocchietti M, Amore A, Peruzzi L, Coppo R, Salvadori M, Ravani P, Magistroni R, Ghiggeri GM, Caridi G, Bodria M, Lugani F, Allegri L, Delsante M, Maiorana M, Magnano A, Frasca G, Boer E, Boscutti G, Ponticelli C, Mignani R, Marcantoni C, Di Landro D, Santoro D, Pani A, Polci R, Feriozzi S, Chicca S, Galliani M, Gigante M, Gesualdo L, Zamboli P, Battaglia GG, Garozzo M, Maixnerová D, Tesar V, Eitner F, Rauen T, Floege J, Kovacs T, Nagy J, Mucha K, PÄ…czek L, Zaniew M, Mizerska-Wasiak M, Roszkowska-Blaim M, Pawlaczyk K, Gale D, Barratt J, Thibaudin L, Berthoux F, Canaud G, Boland A, Metzger M, Panzer U, Suzuki H, Goto S, Narita I, Caliskan Y, Xie J, Hou P, Chen N, Zhang H, Wyatt RJ, Novak J, Julian BA, Feehally J, Stengel B, Cusi D, Lifton RP, Gharavi AG. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nature Genetics 2014 doi: 10.1038/ng.3118.